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Optimized detection of homologous recombination deficiency improves the prediction of clinical outcomes in cancer

29 Dec 2022

Abstract excerpt

Homologous recombination DNA-repair deficiency (HRD) is a common driver of genomic instability and confers a therapeutic vulnerability in cancer. The accurate detection of somatic allelic imbalances (AIs) has been limited by methods focused on BRCA1/2 mutations and using mixtures of cancer types. Using pan-cancer data, we revealed distinct patterns of AIs in high-grade serous ovarian cancer (HGSC). We used...

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PMID: 36581696
DOI: 10.1038/s41698-022-00339-8

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