Article
Increased homozygosity due to endogamy results in fitness consequences in a human population
2022-07-26
Abstract excerpt
Recessive alleles have been shown to directly affect both human Mendelian disease phenotypes and complex traits like height. Pedigree studies also suggest that consanguinity results in increased childhood mortality and adverse health phenotypes, presumably through penetrance of recessive mutations. Here, we test whether the accumulation of homozygous, recessive alleles decreases reproductive success in a human pop...
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Identifiers and source
- Literature Corpus work
- 9714c83a-4da0-5202-9a65-a8d4ca361494
- DOI
- 10.1101/2022.07.25.501261