Article
Estimation of Recent and Ancient Inbreeding in a Small Endogamous Tunisian Community Through Genomic Runs of Homozygosity.
Annals of human genetics - 1 Nov 2015
Ben Halim Nizar, Nagara Majdi, Regnault Béatrice, Hsouna Sana, Lasram Khaled, Kefi Rym, Azaiez Hela, Khemira Laroussi, Saidane Rachid, Ammar Slim Ben, Besbes Ghazi, Weil Dominique, Petit Christine, Abdelhak Sonia, Romdhane Lilia
Abstract excerpt
Runs of homozygosity (ROHs) are extended genomic regions of homozygous genotypes that record populations' mating patterns in the past. We performed microarray genotyping on 15 individuals from a small isolated Tunisian community. We estimated the individual and population genome-wide level of homozygosity from data on ROH above 0.5 Mb in length. We found a high average number of ROH per individual (48.2). The...
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