Article

Autophagy-Mediated Clearance of free Genomic DNA in the Cytoplasm Protects the Growth and Survival of Cancer Cells

2021-02-12

Abstract excerpt

<h4>Background: </h4> The cGAS (GMP-AMP synthase)-triggered senescence-associated secretory phenotype (SASP) in promotion of cancer progression has been extensively documented. However, the role of cGAS-mediated DNA autophagy is little evaluated in cancer cells. <h4>Methods: </h4> Immunofluorescence, senescence associated-β-galactosidase staining (SA-β-gal) and Western blot were performed to detect gene expression...

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Literature Corpus work: 96cd8586-db84-5331-ad22-3c559a83d617
DOI: 10.21203/rs.3.rs-201782/v1

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