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Article

Repair, Reuse, Recycle: The Expanding Role of Autophagy in Genome Maintenance

21 Dec 2016

Abstract excerpt

(Macro)Autophagy is a catabolic pathway that delivers excess, aggregated, or damaged proteins and organelles to lysosomes for degradation. Autophagy is activated in response to numerous cellular stressors such as increased levels of reactive oxygen species (ROS) and low levels of cellular nutrients as well as DNA damage. Although autophagy occurs in the cytoplasm, its inhibition leads to accumulation of DNA...

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PMID: 28011061
DOI: 10.1016/j.tcb.2016.11.011

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