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The interplay between DNA repair and autophagy in cancer therapy

18 May 2015

Abstract excerpt

DNA is the prime target of anticancer treatments. DNA damage triggers a series of signaling cascades promoting cellular survival, including DNA repair, cell cycle arrest, and autophagy. The elevated basal and/or stressful levels of both DNA repair and autophagy observed in tumor cells, in contrast to normal cells, have been identified as the most important drug-responsive programs that impact the outcome of...

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PMID: 25985143
DOI: 10.1080/15384047.2015.1046022

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