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Article

LeMeDISCO is a computational method for large-scale prediction & molecular interpretation of disease comorbidity.

Communications biology - 25 Aug 2022

Astore Courtney, Zhou Hongyi, Ilkowski Bartosz, Forness Jessica, Skolnick Jeffrey

Abstract excerpt

To understand the origin of disease comorbidity and to identify the essential proteins and pathways underlying comorbid diseases, we developed LeMeDISCO (Large-Scale Molecular Interpretation of Disease Comorbidity), an algorithm that predicts disease comorbidities from shared mode of action proteins predicted by the artificial intelligence-based MEDICASCY algorithm. LeMeDISCO was applied to predict the occurrence...

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Identifiers

PMID: 36008469
DOI: 10.1038/s42003-022-03816-9
PMCID: PMC9411158

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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