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The Low expression of PAI-1 increasing MC3T3-E1 cell proliferation by promoting glucose metabolism and activating BMP/TGF-β/Smad and Wnt/β-catenin pathways: a downstream regulatory role of PAI-1 in osteoblasts

2022-12-29

Abstract excerpt

<title>Abstract</title><p>PAI-1 is a marker of aging and a mediator of aging induction. Our previous study showed that PAI-1 is highly expressed in bone tissues of osteoporosis patients. Gavage of osteoporosis model mice with PAI-1 inhibitor resulted in increased Osteoblasts and bone mineral density. Inhibition of PAI-1 expression in MC3T3-E1 cells found that the altered transcription factors were mainly enriched...

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Literature Corpus work
96970538-0b57-57a4-9887-3a63815258e3
DOI
10.21203/rs.3.rs-2333328/v1
Open publication

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The Low expression of PAI-1 increasing MC3T3-E1 cell proliferation by promoting glucose metabolism and activating BMP/TGF-β/Smad and Wnt/β-catenin pathways: a downstream regulatory role of PAI-1 in osteoblastsDOI 10.21203/rs.3.rs-2333328/v1
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