Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids.

doi:10.1038/nm.3973

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Article

Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids.

Nature medicine - 1 Nov 2015

Huang Ling, Holtzinger Audrey, Jagan Ishaan, BeGora Michael, Lohse Ines, Ngai Nicholas, Nostro Cristina, Wang Rennian, Muthuswamy Lakshmi B, Crawford Howard C, Arrowsmith Cheryl, Kalloger Steve E, Renouf Daniel J, Connor Ashton A, Cleary Sean, Schaeffer David F, Roehrl Michael, Tsao Ming-Sound, Gallinger Steven, Keller Gordon, Muthuswamy Senthil K

Abstract excerpt

There are few in vitro models of exocrine pancreas development and primary human pancreatic adenocarcinoma (PDAC). We establish three-dimensional culture conditions to induce the differentiation of human pluripotent stem cells into exocrine progenitor organoids that form ductal and acinar structures in culture and in vivo. Expression of mutant KRAS or TP53 in progenitor organoids induces mutation-specific...

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PMID: 26501191
DOI: 10.1038/nm.3973
PMCID: PMC4753163

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SOX9
KRAS

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