Article
Intradermal delivery of TLR agonists in a human explant skin model: preferential activation of migratory dendritic cells by polyribosinic-polyribocytidylic acid and peptidoglycans.
Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2013
Oosterhoff Dinja, Heusinkveld Moniek, Lougheed Sinéad M, Kosten Ilona, Lindstedt Malin, Bruijns Sven C M, van Es Thomas, van Kooyk Yvette, van der Burg Sjoerd H, de Gruijl Tanja D
Abstract excerpt
TLR agonists are attractive candidate adjuvants for therapeutic cancer vaccines as they can induce a balanced humoral and T cell-mediated immune response. With a dense network of dendritic cells (DCs) and draining lymphatics, the skin provides an ideal portal for vaccine delivery. Beside direct DC activation, TLR agonists may also induce DC activation through triggering the release of inflammatory mediators by...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.