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Article

CXCL4 Exposure Potentiates TLR-Driven Polarization of Human Monocyte-Derived Dendritic Cells and Increases Stimulation of T Cells.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2017

Silva-Cardoso Sandra C, Affandi Alsya J, Spel Lotte, Cossu Marta, van Roon Joel A G, Boes Marianne, Radstake Timothy R D J

Abstract excerpt

Chemokines have been shown to play immune-modulatory functions unrelated to steering cell migration. CXCL4 is a chemokine abundantly produced by activated platelets and immune cells. Increased levels of circulating CXCL4 are associated with immune-mediated conditions, including systemic sclerosis. Considering the central role of dendritic cells (DCs) in immune activation, in this article we addressed the effect...

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Identifiers

PMID: 28515281
DOI: 10.4049/jimmunol.1602020

Genes

TLR3
TLR7
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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