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TLR7 and RIG-I dual-adjuvant loaded nanoparticles drive broadened and synergistic responses in dendritic cells <i>in vitro</i> and generate unique cellular immune responses in influenza vaccination

2020-07-17

Abstract excerpt

<h4>ABSTRACT</h4> Although the existing flu vaccines elicit strong antigen-specific antibody responses, they fail to provide effective, long term protection – partly due to the absence of robust cellular memory immunity. We hypothesized that co-administration of combination adjuvants, mirroring the flu-virus related innate signaling pathways, could elicit strong cellular immunity. Here, we show that the small mol...

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Literature Corpus work
c4c17d3f-c94b-546a-9f5f-6e242bd9bb2a
DOI
10.1101/2020.07.17.207423
Open publication

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TLR7 and RIG-I dual-adjuvant loaded nanoparticles drive broadened and synergistic responses in dendritic cells <i>in vitro</i> and generate unique cellular immune responses in influenza vaccinationDOI 10.1101/2020.07.17.207423
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