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Article

Interferon-β paracrine signaling mediates synergy between TLR3 and TRIF-independent TLR pathways

2025-05-17

Abstract excerpt

Cytokine dysregulation during microbial infections can dangerously increase the severity of associated diseases. Non-additive responses to simultaneous activation of toll-like receptor (TLR) signaling pathways are one potential contributor. Here we explored mechanisms underlying the TLR2/MyD88 and TLR3/TRIF-mediated responses in macrophages for canonical pro-inflammatory and antiviral targets including TNF, IL-6,...

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Identifiers and source

Literature Corpus work
0f1174d9-10c6-5c71-b7d6-a40259f92cda
DOI
10.1101/2025.05.13.653801
Open publication

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Interferon-β paracrine signaling mediates synergy between TLR3 and TRIF-independent TLR pathwaysDOI 10.1101/2025.05.13.653801
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