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Distinct functions of wild-type and R273H mutant Δ133p53α differentially regulate glioblastoma aggressiveness and therapy-induced senescence

2023-11-02

Abstract excerpt

<title>Abstract</title> <p>Mutations effects on p53 isoforms’ activities remain largely unknown, although they are mutated in 92% of <italic>TP53</italic> mutant cancers. Therefore, exploring the effect of mutations on p53 isoforms activities is a critical, albeit unexplored area in the p53 field. In this article, we report for the first time a mutant Δ133p53α-specific pathway which increases IL4I1 and IDO1 expre...

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Literature Corpus work
965010fd-01aa-5172-a795-ff60ba056cf0
DOI
10.21203/rs.3.rs-3370608/v1
Open publication

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Distinct functions of wild-type and R273H mutant Δ133p53α differentially regulate glioblastoma aggressiveness and therapy-induced senescenceDOI 10.21203/rs.3.rs-3370608/v1
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