Exploring p53 Isoforms: Unraveling Heterogeneous p53 Tumor Suppressor Functionality in Uveal Melanoma

Abstract excerpt

<title>Abstract</title> <p> Uveal melanoma (UM) is the most common intraocular tumor, and despite being rare, it accounts for nearly 13% of melanoma-related deaths. Indeed, patients with metastatic disease have typically a survival rate of less than one year, with little improvement over the past few decades. Although <italic>TP53</italic> mutations are uncommon in UM, recent findings highlight a dysfunctional...

Topics

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• Cancer-related Molecular Pathways
• Cancer Research and Treatments
• Melanoma
• Melanoma and MAPK Pathways
• Mutation
• Ubiquitin Thiolesterase
• Uveal Melanoma
• Uveal Neoplasms

Identifiers and source

Literature Corpus work

469993b5-7e2f-51e1-90f0-efd94e23acfd

DOI

10.21203/rs.3.rs-6277392/v1