Article

Enhanced Cytotoxicity against Cholangiocarcinoma by Fifth-Generation Chimeric Antigen Receptor T Cells Targeting Integrin αvβ6 and Secreting Anti-PD-L1 scFv

2024-12-17

Abstract excerpt

<title>Abstract</title> <p>Cholangiocarcinoma (CCA) is a fatal bile duct cancer with high resistance and recurrence rates, with only one fifth of patients eligible for surgical treatment. The disease resists standard chemotherapy and often relapses. Chimeric antigen receptor (CAR) T cell therapy has shown promise for hematological malignancies but faces challenges in solid tumors due to resistance mechanisms like...

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Literature Corpus work: 1fea531f-9cae-58d5-8deb-31cfe569d0d2
DOI: 10.21203/rs.3.rs-5355014/v1

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Enhanced Cytotoxicity against Cholangiocarcinoma by Fifth-Generation Chimeric Antigen Receptor T Cells Targeting Integrin αvβ6 and Secreting Anti-PD-L1 scFvDOI 10.21203/rs.3.rs-5355014/v1Read

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