Article

Human Embryonic Expression Identifies Novel Essential Gene Candidates

2020-08-15

Abstract excerpt

Disruption of essential genes leads to pregnancy loss, early lethality, or severe disease. Current methods to predict genes that underlie severe phenotypes include knockout animal model systems, evolutionary conservation, and variation intolerance metrics. With existing methods, human lethal genes are missed due to interspecies differences or paucity of gene characterization. We analyzed global gene expression in...

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Literature Corpus work: c18ea464-99b3-5fe8-b6c4-57108b025a76
DOI: 10.1101/2020.08.15.252338

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