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Article

Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons.

Cell reports - 10 Apr 2014

Wainger Brian J, Kiskinis Evangelos, Mellin Cassidy, Wiskow Ole, Han Steve S W, Sandoe Jackson, Perez Numa P, Williams Luis A, Lee Seungkyu, Boulting Gabriella, Berry James D, Brown Robert H, Cudkowicz Merit E, Bean Bruce P, Eggan Kevin, Woolf Clifford J

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of the motor nervous system. We show using multielectrode array and patch-clamp recordings that hyperexcitability detected by clinical neurophysiological studies of ALS patients is recapitulated in induced pluripotent stem cell-derived motor neurons from ALS patients harboring superoxide dismutase 1 (SOD1), C9orf72, and fused-in-sarcoma...

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Identifiers

PMID: 24703839
DOI: 10.1016/j.celrep.2014.03.019
PMCID: PMC4023477

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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