Article

Sex as a critical variable in basic and pre-clinical studies of fibrodysplasia ossificans progressiva

2023-12-25

Abstract excerpt

Heterotopic ossification (HO) is most dramatically manifested in the rare and severely debilitating disease, fibrodysplasia ossificans progressiva (FOP), in which heterotopic bone progressively accumulates in skeletal muscles and associated soft tissues. The great majority of FOP cases are caused by a single amino acid substitution in the type 1 bone morphogenetic protein (BMP) receptor ACVR1, a mutation that impa...

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Literature Corpus work: 95ef9052-a1d2-5b78-96f6-935753b02f0e
DOI: 10.20944/preprints202312.1827.v1

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