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Article

The obligatory role of Activin A in the formation of heterotopic bone in Fibrodysplasia Ossificans Progressiva.

Bone - 1 Apr 2018

Alessi Wolken Dana M, Idone Vincent, Hatsell Sarah J, Yu Paul B, Economides Aris N

Abstract excerpt

Fibrodysplasia Ossificans Progressiva (FOP) is a rare genetic disorder that presents at birth with only minor patterning defects, but manifests its debilitating pathology early in life with episodic, yet progressive and cumulative, heterotopic ossification (HO) of ligaments, tendons, and a subset of major skeletal muscles. The resulting HO lesions are endochondral in nature, and appear to be linked to...

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Share to Activin Receptors, Type I
Share to Activins
Share to ACVR1 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Myositis Ossificans

Share to Ossification, Heterotopic

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Source

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Identifiers

PMID: 28629737
DOI: 10.1016/j.bone.2017.06.011
PMCID: PMC6706059

Genes

ACVR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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