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Over-expression of wild-type <i>ACVR1</i> in fibrodysplasia ossificans progressiva mice rescues perinatal lethality and inhibits heterotopic ossification

2021-12-08

Abstract excerpt

Fibrodysplasia ossificans progressiva (FOP) is a devastating disease of progressive heterotopic bone formation for which effective treatments are currently unavailable. FOP is caused by dominant gain-of-function mutations in the receptor ACVR1 (also known as ALK2), which render the receptor inappropriately responsive to activin ligands. In previous studies, we developed a genetic mouse model of FOP that recapitula...

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Literature Corpus work
35f518c8-5139-5432-b9b2-a7beeaae7996
DOI
10.1101/2021.12.08.471385
Open publication

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Over-expression of wild-type <i>ACVR1</i> in fibrodysplasia ossificans progressiva mice rescues perinatal lethality and inhibits heterotopic ossificationDOI 10.1101/2021.12.08.471385
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