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Article

Fibrodysplasia ossificans progressiva: mechanisms and models of skeletal metamorphosis.

Disease models & mechanisms - 1 Nov 2012

Kaplan Frederick S, Chakkalakal Salin A, Shore Eileen M

Abstract excerpt

Fibrodysplasia ossificans progressiva (FOP; MIM #135100) is a debilitating genetic disorder of connective tissue metamorphosis. It is characterized by malformation of the great (big) toes during embryonic skeletal development and by progressive heterotopic endochondral ossification (HEO) postnatally, which leads to the formation of a second skeleton of heterotopic bone. Individuals with these classic clinical...

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Share to Bone Development
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Metamorphosis, Biological

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Source

Open in PubMed Open full text

Identifiers

PMID: 23115204
DOI: 10.1242/dmm.010280
PMCID: PMC3484858

Genes

ACVR1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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