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Article

An anti-ACVR1 antibody exacerbates heterotopic ossification by fibro-adipogenic progenitors in fibrodysplasia ossificans progressiva mice.

The Journal of clinical investigation - 15 Jun 2022

Lees-Shepard John B, Stoessel Sean J, Chandler Julian T, Bouchard Keith, Bento Patricia, Apuzzo Lorraine N, Devarakonda Parvathi M, Hunter Jeffrey W, Goldhamer David J

Abstract excerpt

Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease characterized by progressive and catastrophic heterotopic ossification (HO) of skeletal muscle and associated soft tissues. FOP is caused by dominantly acting mutations in the gene encoding the bone morphogenetic protein (BMP) type I receptor, ACVR1 (ALK2), the most prevalent of which results in an arginine to histidine substitution at position...

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Identifiers

PMID: 35503416
DOI: 10.1172/JCI153795
PMCID: PMC9197527

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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An anti-ACVR1 antibody exacerbates heterotopic ossification by fibro-adipogenic progenitors in fibrodysplasia ossificans progressiva mice.PMID 35503416Read ↗

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