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Article

BMP signaling and skeletal development in fibrodysplasia ossificans progressiva (FOP).

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jan 2022

Towler Oscar Will, Shore Eileen M

Abstract excerpt

Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare genetic disease caused by increased BMP pathway signaling due to mutation of ACVR1, a bone morphogenetic protein (BMP) type 1 receptor. The primary clinical manifestation of FOP is extra-skeletal bone formation (heterotopic ossification) within soft connective tissues. However, the underlying ACVR1 mutation additionally alters skeletal bone development...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34133058
DOI: 10.1002/dvdy.387
PMCID: PMC9068236

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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