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Article

Oncogenic BRAFV600E inhibits BIM expression to promote melanoma cell survival

26 Jul 2008

Abstract excerpt

Somatic activating mutations of BRAF are the earliest and most common genetic abnormality detected in the genesis of human melanoma. However, the mechanism(s) by which activated BRAF promotes melanoma cell cycle progression and/or survival remain unclear. Here we demonstrate that expression of BIM, a pro-apoptotic member of the BCL-2 family, is inhibited by BRAF-->MEK-->ERK signaling in mouse and human...

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PMID: 18715233
DOI: 10.1111/j.1755-148x.2008.00491.x

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Oncogenic BRAFV600E inhibits BIM expression to promote melanoma cell survivalPMID 18715233Read ↗

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