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Article

Darier disease: a guide to the physician.

Journal of medicine - 1 Jan 2004

Godic Aleksandar

Abstract excerpt

Darier disease is an autosomal dominant skin disorder, characterized by follicular and extrafollicular keratotic papules, primarily in seborrheic areas. It is caused by mutations of ATP2A2 gene, which encodes the sarco/endoplasmic reticulum Ca2+ ATPase isoform 2 (SERCA2 protein). SERCA pumps maintain low cytosolic Ca2+ concentration by actively transporting Ca2+ from the cytosol into the sarco/endoplasmic...

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PMID: 18084860

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