Article

Oxidized thioredoxin-1 restrains the NLRP1 inflammasome

2021-09-20

Abstract excerpt

At least six human proteins detect danger-associated signals, assemble into complexes called inflammasomes, and trigger pyroptotic cell death. NLRP1 was the first protein discovered to form an inflammasome, but the danger signals and molecular mechanisms that control its activation have not yet been fully established. Here, we report that the NACHT-LRR region of NLRP1 directly binds to oxidized form of thioredoxin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f1a279d7-e21d-5b61-927b-86981f26fc0e
DOI: 10.1101/2021.09.20.461118

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Oxidized thioredoxin-1 restrains the NLRP1 inflammasomeDOI 10.1101/2021.09.20.461118Read

To protect or adversely affect? The dichotomous role of the NLRP1 inflammasome in human diseaseSemantic proximity Read

Life-threatening risk factors contribute to the development of diseases with the highest mortality through the induction of regulated necrotic cell deathSemantic proximity Read

NLRP3 inflammasome: from a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases.Semantic proximity Read

Mystery machine: the complex roles of NLRX1 in viral infectionSemantic proximity Read

APE1/Ref-1 Role in Inflammation and Immune ResponseSemantic proximity Read

Trxlp, a thioredoxin-like effector from Edwardsiella piscicida inhibits cellular redox signaling and nuclear translocation of NF-κB.Semantic proximity Read

A pan-cancer analysis of thioredoxin-interacting protein as an immunological and prognostic biomarkerSemantic proximity Read

Peroxiredoxin 1 (Prx1) is a dual-function enzyme by possessing Cys-independent catalase-like activity.Semantic proximity Read

Biochemical and structural aspects of the ATP‐binding domain in inflammasome‐forming human NLRP proteinsSemantic proximity Read

P2RX7 at the Host-Pathogen Interface of Infectious DiseasesSemantic proximity Read

Nox Enzymes and New Thinking on Reactive Oxygen: A Double-Edged Sword RevisitedSemantic proximity Read

Thioredoxin regulates the redox state and the activity of the human tRNA ligase complexSemantic proximity Read