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Article

S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury.

Science (New York, N.Y.) - 3 Apr 2009

Cho Dong-Hyung, Nakamura Tomohiro, Fang Jianguo, Cieplak Piotr, Godzik Adam, Gu Zezong, Lipton Stuart A

Abstract excerpt

Mitochondria continuously undergo two opposing processes, fission and fusion. The disruption of this dynamic equilibrium may herald cell injury or death and may contribute to developmental and neurodegenerative disorders. Nitric oxide functions as a signaling molecule, but in excess it mediates neuronal injury, in part via mitochondrial fission or fragmentation. However, the underlying mechanism for nitric...

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Identifiers

PMID: 19342591
DOI: 10.1126/science.1171091
PMCID: PMC2823371

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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