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The construction of a testis transcriptional cell atlas from embryo to adult reveals various somatic cells and their molecular roles

27 Nov 2023

Abstract excerpt

BACKGROUND: The testis is a complex organ that undergoes extensive developmental changes from the embryonic stage to adulthood. The development of germ cells, which give rise to spermatozoa, is tightly regulated by the surrounding somatic cells. METHODS: To better understand the dynamics of these changes, we constructed a transcriptional cell atlas of the testis, integrating single-cell RNA sequencing data from...

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PMID: 38012716
DOI: 10.1186/s12967-023-04722-2

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