Article

Small Molecule Induced Toxic Human-IAPP Species Characterized by NMR

2019-11-24

Abstract excerpt

In this study, the effect of CurDAc, a water-soluble curcumin derivative, on the formation and stability of amyloid fibers is revealed. CurDAc interaction with amyloid is structurally selective which is reflected in a strong interference with hIAPP aggregation, while showing weaker interactions with human-calcitonin and Amyloid-β 1-40 in comparison. Remarkably, CurDAc also exhibited potent fiber disaggregation fo...

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Literature Corpus work: 959da3a2-f496-51eb-849d-b035e3676aa0
DOI: 10.1101/853549

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