Article
Common fibrillar spines of amyloid-β and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors.
The Journal of biological chemistry - 23 Feb 2018
Krotee Pascal, Griner Sarah L, Sawaya Michael R, Cascio Duilio, Rodriguez Jose A, Shi Dan, Philipp Stephan, Murray Kevin, Saelices Lorena, Lee Ji, Seidler Paul, Glabe Charles G, Jiang Lin, Gonen Tamir, Eisenberg David S
Abstract excerpt
Amyloid-β (Aβ) and human islet amyloid polypeptide (hIAPP) aggregate to form amyloid fibrils that deposit in tissues and are associated with Alzheimer's disease (AD) and type II diabetes (T2D), respectively. Individuals with T2D have an increased risk of developing AD, and conversely, AD patients have an increased risk of developing T2D. Evidence suggests that this link between AD and T2D might originate from a...
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