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Structure-Guided Design of Planarized Catechin Derivatives: Enhancing Antioxidant and Multifaceted Biological Activities for Therapeutic Applications

2026-07-21

Abstract excerpt

Oxidative stress is a major driver of chronic disease, making natural polyphenols attractive scaffolds for modulating inflammation, proteostasis, and cell fate. However, green-tea catechins possess a twisted, conformationally flexible flavan-3-ol framework that limits π-conjugation, phenoxyl-radical stabilization, and productive interactions with biological targets. This review presents a structure-based framework...

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Literature Corpus work
d183272f-24b9-5622-97ee-073eed6b7222
DOI
10.20944/preprints202607.1544.v1
Open publication

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Structure-Guided Design of Planarized Catechin Derivatives: Enhancing Antioxidant and Multifaceted Biological Activities for Therapeutic ApplicationsDOI 10.20944/preprints202607.1544.v1
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