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Article

The role of microenvironment in the initiation and evolution of B-cell precursor acute lymphoblastic leukemia

7 Mar 2023

Abstract excerpt

B cell precursor acute lymphoblastic leukemia (BCP-ALL) is a malignant disorder of immature B lineage immune progenitors and is the commonest cancer in children. Despite treatment advances it remains a leading cause of death in childhood and response rates in adults remain poor. A preleukemic state predisposing children to BCP-ALL frequently arises in utero, with an incidence far higher than that of transformed...

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PMID: 36959797
DOI: 10.3389/fonc.2023.1150612

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