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Article

Single-cell developmental classification of B cell precursor acute lymphoblastic leukemia at diagnosis reveals predictors of relapse.

Nature medicine - 1 May 2018

Good Zinaida, Sarno Jolanda, Jager Astraea, Samusik Nikolay, Aghaeepour Nima, Simonds Erin F, White Leah, Lacayo Norman J, Fantl Wendy J, Fazio Grazia, Gaipa Giuseppe, Biondi Andrea, Tibshirani Robert, Bendall Sean C, Nolan Garry P, Davis Kara L

Abstract excerpt

Insight into the cancer cell populations that are responsible for relapsed disease is needed to improve outcomes. Here we report a single-cell-based study of B cell precursor acute lymphoblastic leukemia at diagnosis that reveals hidden developmentally dependent cell signaling states that are uniquely associated with relapse. By using mass cytometry we simultaneously quantified 35 proteins involved in B cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29505032
DOI: 10.1038/nm.4505
PMCID: PMC5953207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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