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Frameshift and frame-preserving mutations in zebrafish <i>presenilin 2</i> affect different cellular functions in young adult brains

2020-11-22

Abstract excerpt

<h4>Background</h4> Mutations in PRESENILIN 2 ( PSEN2 ) cause early disease onset familial Alzheimer’s disease (EOfAD) but their mode of action remains elusive. One consistent observation for all PRESENILIN gene mutations causing EOfAD is that a transcript is produced with a reading frame terminated by the normal stop codon – the “reading frame preservation rule”. Mutations that do not obey this rule do not ca...

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Literature Corpus work
9562aeab-ced4-504c-975e-221d96814997
DOI
10.1101/2020.11.21.392761
Open publication

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Frameshift and frame-preserving mutations in zebrafish <i>presenilin 2</i> affect different cellular functions in young adult brainsDOI 10.1101/2020.11.21.392761
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