Article

A familial Alzheimer's disease-like mutation in the zebrafish <i>presenilin 1</i> gene affects brain energy production

2019-02-06

Abstract excerpt

To prevent or ameliorate Alzheimer's disease (AD) we must understand its molecular basis. AD develops over decades but detailed molecular analysis of AD brains is limited to postmortem tissue where the stresses initiating the disease may be obscured by compensatory responses and neurodegenerative processes. Rare, dominant mutations in a small number of genes, but particularly the gene PRESENILIN 1 ( PSEN1 ), dri...

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Literature Corpus work: 923b9851-8ec3-540f-9ebb-8f999efc2b55
DOI: 10.1101/542134

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