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Brain transcriptome analysis reveals subtle effects on mitochondrial function and iron homeostasis of mutations in the <i>SORL1</i> gene implicated in early onset familial Alzheimer’s disease

2020-07-17

Abstract excerpt

<h4>Background</h4> To prevent or delay the onset of Alzheimer’s disease (AD), we must understand its molecular basis. The great majority of AD cases arise sporadically with a late onset after 65 years of age (LOAD). However, rare familial cases of AD can occur due to dominant mutations in a small number of genes that cause an early onset prior to 65 years of age (EOfAD). As EOfAD and LOAD share similar pathologi...

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Literature Corpus work
c419e978-ab00-52d5-b1f1-e8aaa9969a94
DOI
10.1101/2020.07.17.207787
Open publication

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Brain transcriptome analysis reveals subtle effects on mitochondrial function and iron homeostasis of mutations in the <i>SORL1</i> gene implicated in early onset familial Alzheimer’s diseaseDOI 10.1101/2020.07.17.207787
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