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Transcriptome analysis of a protein-truncating mutation in <i>sortilin-related receptor 1</i> associated with early-onset familial Alzheimer’s disease indicates effects on mitochondrial and ribosome function in young-adult zebrafish brains

2020-09-04

Abstract excerpt

The early cellular stresses which eventually lead to Alzheimer’s disease (AD) remain poorly understood because we cannot access living, asymptomatic human AD brains for detailed molecular analyses. Sortilin-related receptor 1 ( SORL1 ) encodes a multi-domain receptor protein genetically associated with both rare, early-onset familial AD (EOfAD) and common, sporadic late-onset AD (LOAD). SORL1 has been shown to pl...

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Literature Corpus work
cd0c7db1-47d8-5277-b78f-c8cf492af273
DOI
10.1101/2020.09.03.282277
Open publication

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Transcriptome analysis of a protein-truncating mutation in <i>sortilin-related receptor 1</i> associated with early-onset familial Alzheimer’s disease indicates effects on mitochondrial and ribosome function in young-adult zebrafish brainsDOI 10.1101/2020.09.03.282277
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