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The zebrafish orthologue of familial Alzheimer’s disease gene <i>PRESENILIN</i> 2 is required for normal adult melanotic skin pigmentation

2018-09-11

Abstract excerpt

Alzheimer’s disease is the most common form of age-related dementia. At least 15 mutations in the human gene PRESENILIN 2 ( PSEN2 ) have been found to cause familial Alzheimer’s disease (fAD). Zebrafish possess an orthologous gene, psen2 , and present opportunities for investigation of PRESENILIN function related to Alzheimer’s disease. The most prevalent and best characterized fAD mutation in PSEN2 is N141I...

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Literature Corpus work
c87419f6-114e-5135-804d-8cbc120c646b
DOI
10.1101/414144
Open publication

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The zebrafish orthologue of familial Alzheimer’s disease gene <i>PRESENILIN</i> 2 is required for normal adult melanotic skin pigmentationDOI 10.1101/414144
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