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Transcriptome analysis indicates dominant effects on ribosome and mitochondrial function of a premature termination codon mutation in the zebrafish gene <i>psen2</i>

2020-04-20

Abstract excerpt

PRESENILIN 2 ( PSEN2 ) is one of the genes mutated in early onset familial Alzheimer’s disease (EOfAD). PSEN2 shares significant amino acid sequence identity with another EOfAD-related gene PRESENILIN 1 ( PSEN1 ), and partial functional redundancy is seen between these two genes. However, the complete range of functions of PSEN1 and PSEN2 is not yet understood. In this study, we performed targeted mutagenesi...

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Literature Corpus work
0e1b3063-6844-5707-aff5-58a16a58957b
DOI
10.1101/2020.04.20.050815
Open publication

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Transcriptome analysis indicates dominant effects on ribosome and mitochondrial function of a premature termination codon mutation in the zebrafish gene <i>psen2</i>DOI 10.1101/2020.04.20.050815
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