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Article

Lysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance.

Nature communications - 22 Jan 2018

Cotte Alexia Karen, Aires Virginie, Fredon Maxime, Limagne Emeric, Derangère Valentin, Thibaudin Marion, Humblin Etienne, Scagliarini Alessandra, de Barros Jean-Paul Pais, Hillon Patrick, Ghiringhelli François, Delmas Dominique

Abstract excerpt

Lipid droplet (LD) accumulation is a now well-recognised hallmark of cancer. However, the significance of LD accumulation in colorectal cancer (CRC) biology is incompletely understood under chemotherapeutic conditions. Since drug resistance is a major obstacle to treatment success, we sought to determine the contribution of LD accumulation to chemotherapy resistance in CRC. Here we show that LD content of CRC...

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Identifiers

PMID: 29358673
DOI: 10.1038/s41467-017-02732-5
PMCID: PMC5778070

Genes

LPCAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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