Article

Substrate displacement of CK1 C-termini regulates kinase specificity

2023-07-01

Abstract excerpt

CK1 kinases participate in many signaling pathways; how these enzymes are regulated is therefore of significant biological consequence. CK1s autophosphorylate their C-terminal non-catalytic tails, and eliminating these modifications increases substrate phosphorylation in vitro, suggesting that the autophosphorylated C-termini act as inhibitory pseudosubstrates. To test this prediction, we comprehensively identifie...

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Literature Corpus work: 95360ed2-ee64-56d5-b608-b0d07da106e6
DOI: 10.1101/2023.06.30.547285

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