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A lncRNA from an inflammatory bowel disease risk locus maintains intestinal host-commensal homeostasis

13 Apr 2023

Abstract excerpt

Inflammatory bowel diseases (IBD) are known to have complex, genetically influenced etiologies, involving dysfunctional interactions between the intestinal immune system and the microbiome. Here, we characterized how the RNA transcript from an IBD-associated long non-coding RNA locus ("CARINH-Colitis Associated IRF1 antisense Regulator of Intestinal Homeostasis") protects against IBD. We show that CARINH and its...

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PMID: 37055591
DOI: 10.1038/s41422-023-00790-7

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