Article

Inactivation of the ATM Gene in T-Cell Prolymphocytic Leukemias

1998-05-15

Abstract excerpt

T-cell prolymphocytic leukemia (T-PLL) is a rare form of mature leukemia that occurs both in adults as a sporadic disease and in younger patients suffering an hereditary condition, ataxia telangiectasia (AT). The ATM gene, located in the 11q22-23 chromosomal region, is consistently mutated in AT patients. The strong predisposition of AT patients to develop T-PLL and the high frequency of T-cell leukemias/lymphomas...

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Literature Corpus work: 952c3546-f338-5149-9c6e-862be789d137
DOI: 10.1182/blood.v91.10.3920.3920_3920_3926

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