Article
Germ-line ATM gene alterations are associated with susceptibility to sporadic T-cell acute lymphoblastic leukemia in children.
Genes, chromosomes & cancer - 1 Feb 2004
Liberzon Ella, Avigad Smadar, Stark Batia, Zilberstein Julia, Freedman Laurence, Gorfine Malka, Gavriel Herzel, Cohen Ian J, Goshen Yacov, Yaniv Isaac, Zaizov Rina
Abstract excerpt
A major feature of ataxia-telangiectasia (A-T) is an increased risk of cancer, particularly of lymphoid malignancies. We studied ATM gene involvement in leukemic cells derived from 39 pediatric T-cell acute lymphoblastic leukemias (ALLs). Two types of sequence changes--truncating and missense--were identified in 8 T-cell ALL samples: 3 truncating changes, all previously identified in A-T (R35X, -30del215,...
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