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Article

ATM gene and lymphoid malignancies.

Leukemia - 1 Feb 2004

Gumy-Pause F, Wacker P, Sappino A-P

Abstract excerpt

Inherited biallelic mutations of the ATM (ataxia-telangiectasia mutated) gene cause ataxia-telangiectasia, a rare autosomal recessive disorder associated with a high incidence of childhood leukaemias and lymphomas, suggesting that ATM gene alterations may be involved in lymphomagenesis. Loss of heterozygosity at 11q22-23 (location of the ATM gene) is a frequent event in sporadic lymphoid tumours, and several...

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Source

Identifiers

PMID: 14628072
DOI: 10.1038/sj.leu.2403221

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

ATM gene and lymphoid malignancies.PMID 14628072Read ↗

Ataxia telangiectasia gene mutations in leukaemia and lymphoma.Semantic proximity Read ↗

ATM mutations in sporadic lymphoid tumours.Semantic proximity Read ↗

Clustering of missense mutations in the ataxia-telangiectasia gene in a sporadic T-cell leukaemia.Semantic proximity Read ↗

Somatic ATM Mutations Indicate a Pathogenic Role of ATM in B-Cell Chronic Lymphocytic LeukemiaSemantic proximity Read ↗

Underexpression and abnormal localization of ATM products in ataxia telangiectasia patients bearing ATM missense mutations.Semantic proximity Read ↗

Mantle cell lymphoma is characterized by inactivation of the ATM gene.Semantic proximity Read ↗

ATM mutations in B-cell chronic lymphocytic leukemia.Semantic proximity Read ↗

ATM: Functions of ATM Kinase and Its Relevance to Hereditary Tumors.Semantic proximity Read ↗

Somatic ATM mutations indicate a pathogenic role of ATM in B-cell chronic lymphocytic leukemia.Semantic proximity Read ↗

Germ-line ATM gene alterations are associated with susceptibility to sporadic T-cell acute lymphoblastic leukemia in children.Semantic proximity Read ↗

Biallelic mutations in the ATM gene in T-prolymphocytic leukemia.Semantic proximity Read ↗

ATM germline heterozygosity does not play a role in chronic lymphocytic leukemia initiation but influences rapid disease progression through loss of the remaining ATM allele.Semantic proximity Read ↗

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