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Article

Clustering of missense mutations in the ataxia-telangiectasia gene in a sporadic T-cell leukaemia.

Nature genetics - 1 Sept 1997

Vorechovský I, Luo L, Dyer M J, Catovsky D, Amlot P L, Yaxley J C, Foroni L, Hammarström L, Webster A D, Yuille M A

Abstract excerpt

Ataxia-telangiectasia (A-T) is a recessive multi-system disorder caused by mutations in the ATM gene at 11q22-q23 (ref. 3). The risk of cancer, especially lymphoid neoplasias, is substantially elevated in A-T patients and has long been associated with chromosomal instability. By analysing tumour DNA from patients with sporadic T-cell prolymphocytic leukaemia (T-PLL), a rare clonal malignancy with similarities to...

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PMID: 9288106
DOI: 10.1038/ng0997-96

Genes

ATM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Clustering of missense mutations in the ataxia-telangiectasia gene in a sporadic T-cell leukaemia.PMID 9288106Read ↗

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ATM gene and lymphoid malignancies.Semantic proximity Read ↗

Inactivation of the ATM gene in T-cell prolymphocytic leukemias.Semantic proximity Read ↗

Underexpression and abnormal localization of ATM products in ataxia telangiectasia patients bearing ATM missense mutations.Semantic proximity Read ↗

Ataxia-telangiectasia and T-cell leukemias: no evidence for somatic ATM mutation in sporadic T-ALL or for hypermethylation of the ATM-NPAT/E14 bidirectional promoter in T-PLL.Semantic proximity Read ↗

Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer.Semantic proximity Read ↗

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