Article
The ATM gene and susceptibility to childhood T-cell acute lymphoblastic leukaemia.
British journal of haematology - 1 Nov 1998
Takeuchi S, Koike M, Park S, Seriu T, Bartram C R, Taub H E, Williamson I K, Grewal J, Taguchi H, Koeffler H P
Abstract excerpt
Ataxia-telangiectasia (A-T) is a multisystem recessive disease characterized by cerebellar ataxia, oculocutaneous telangiectasias, immunodeficiency and increased risk of cancer. The ATM gene, responsible for A-T, was recently cloned at human chromosome band 11q22-23, a region of frequent alterati...
Topics
- Ataxia Telangiectasia Mutated Proteins
- Cell Cycle Proteins
- Child
- Chromosomes, Human, Pair 11
- DNA-Binding Proteins
- Genes, Tumor Suppressor
- Genetic Predisposition to Disease
- Humans
- Leukemia-Lymphoma, Adult T-Cell
- Loss of Heterozygosity
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational