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Article

Artesunate inhibits intestinal tumorigenesis through inhibiting wnt signaling.

Carcinogenesis - 11 Feb 2021

Hamoya Takahiro, Fujii Gen, Iizumi Yosuke, Narita Takumi, Komiya Masami, Matsuzawa Yui, Miki Kohei, Kondo Tadashi, Kishimoto Shinji, Watanabe Kenji, Wakabayashi Keiji, Sakai Toshiyuki, Toshima Jiro, Mutoh Michihiro

Abstract excerpt

Artesunate (ART) is a clinically approved antimalarial drug and was revealed as a candidate of colorectal cancer chemopreventive agents in our drug screening system. Here, we aimed to understand the suppressive effects of ART on intestinal tumorigenesis. In vitro, ART reduced T-cell factor/lymphoid enhancer factor (TCF/LEF) promoter transcriptional activity. In vivo, ART inhibited intestinal polyp development. We...

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Identifiers

PMID: 32710739
DOI: 10.1093/carcin/bgaa084

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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