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Article

Effect of casein kinase 1α inhibition on autophagy flux and the AKT/phospho-β-catenin (S552) axis in HCT116, a RAS-mutated colorectal cancer cell line.

Canadian journal of physiology and pharmacology - 1 Mar 2021

Behrouj Hamid, Seghatoleslam Atefeh, Mokarram Pooneh, Ghavami Saeid

Abstract excerpt

The Wnt/β-catenin pathway, which interferes with cell proliferation, differentiation, and autophagy, is commonly dysregulated in colorectal cancer (CRC). Mutation of the RAS oncogene is the most prevalent genetic alteration in CRC and has been linked to activation of protein kinase B (AKT) signaling. Phosphorylation of β-catenin at Ser 552 by AKT contributes to β-catenin stability, transcriptional activity, and...

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PMID: 33635146
DOI: 10.1139/cjpp-2020-0449

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